peritoneal mesothelioma problem

 peritoneal chemotherapy regional multimodal therapy of tumors

Mesothelioma of the peritoneum, peritoneal mesothelioma, peritoneal carcinoma

Every year about 20,000 people in Germany suffering from a cancerous infection of the peritoneum, called peritoneal carcinomatosis. Colorectal carcinoma, gastric carcinoma, small intestine - malignancies and ovarian cancer make it in most cases the origin of such a tumor spread dar. Besides these more common tumor types, there are other, more rare tumor entities such as pseudomyxoma peritonei or peritoneal mesothelioma, leading to a peritoneal tumor involvement lead.

Most patients with a peritoneal infection die within 6 months. In a multicenter, prospective study of 370 patients with peritoneal non-gynecologic primary tumors, the median survival time of 3.1 for the full Monte clientele. Also for the subgroups of gastric cancer (3.1 months), colorectal carcinoma (5.2 months), pancreatic cancer (1.5 months) and the unknown primary tumor CUP (1.5 months), the median survival times extremely short. These data demonstrate the ineffectiveness of previously used treatments such as systemic chemotherapy, "Supportive Care" or radiation.

Pathophysiologically considered results in a peritoneal metastasis through migration and growth of tumor cells in the peritoneum. Such planting can occur either by serosal infiltration in abdominal tumors, lymphatic or hematogenous tumor cell migration, or direct manipulation for examples during the operation.
In the past 10 years, accumulating more and more positive reports on the improvement of the prognosis of patients with overt peritoneal carcinomatosis by multivisceral resection of affected organs in combination with areal removal of the peritoneum and intraperitoneal chemotherapy under hyperthermic conditions.